Dose of Laughter: The Most Unique Stand-Up Comedy Show in San Diego

Looking for unforgettable stand-up comedy in San Diego? Look no further than Dose of Laughter—a one-of-a-kind live comedy experience that brings together hilarious comedians, live music, and a mission to heal through humor.

Founded in 2019 by Registered Nurse and Comedian Chuck Meyers (@chuckmeyers_), Dose of Laughter is more than just a comedy show—it’s comedy with heart. In the same way medicine helps people heal, laughter relieves stress, lifts spirits, and connects us all. Comedy is the best therapy—without the side effects (besides occasionally peeing your pants).

San Diego Comedy Shows That Heal and Entertain

Dose of Laughter has made audiences laugh in San Diego backyards, Manhattan basements, and even on the stages of legendary comedy clubs like Zanies Chicago. Whether you're a local or visiting the area, it's one of the best comedy shows in San Diego for a night out full of laughter and connection.

Each event is a full experience, combining top-tier stand-up comedy with live music for a vibe you won’t find anywhere else in the city.

Featuring Top San Diego Comedians and National Touring Acts

Our shows highlight the best local San Diego comedians along with major national headliners like:

• Jamie Kennedy (@thejamiekennedy)

• Aries Spears (@ariesspears)

• Matthew Broussard (@mondaypunday)

• Mark Normand (@marknormand)

• And many more surprise guests

Whether you’re searching for a comedy show tonight in San Diego, a date night idea, or a unique experience with friends, Dose of Laughter delivers high-energy, heart-forward humor that you’ll be talking about long after the final set.

Don’t Miss One of the Best Comedy Shows in San Diego

Follow @chuckmeyers_ @doseoflaughtersd and stay tuned for upcoming shows, lineups, and tickets. Experience why audiences across the U.S. are calling Dose of Laughter one of the most original and meaningful stand-up comedy events today.